was his second-highest total as a Laker and the most against his first NBA team.
He added eight rebounds, six assists, two steals and two blocks.
James, playing for the second time in Cleveland since he switched to the Lakers in 2018, scored 13 points in the final four minutes and 41 seconds.
It helped the Lakers pull away and claim a 10th win out of 10 on the road this season.
They play in Philadelphia, Bryant’s birthplace, on Wednesday in what will be an emotional occasion.
Anthony Davis had 17 points and 10 rebounds for the Lakers, while Montrezl Harrell scored 15 off the bench.
For the Cavaliers, Andre Drummond had 25 points and 17 rebounds while Cedi Osman scored 20 points and Collin Sexton finished with 17.